POINT (PLATELET-ORIENTED INHIBITION IN NEW TIA AND MINOR ISCHEMIC STROKE TRIAL) – Lead Coordinator: Dominica Randazzo These trials are ALIAS 2, POINT, and SHINE. BASIC, working in conjunction with NETT, is involved in a number of trials that are attempting to find a way to either ease the effects of ischemic strokes or to prevent more serious ischemic strokes in patients who have already suffered small-scale ones. The brain is dependent on arteries to provide it with essential nutrients and oxygen to continue functioning, so when an artery is blocked, extensive tissue damage can occur. Ischemic strokes, or the blocking of an artery that leads to the brain, make up 88 percent of all strokes. Over 140,000 of these incidents are fatal, making strokes the third largest cause of death in the United States. To learn more about NETT and these trials visit: Įvery year over 750,000 people suffer from strokes in the United States alone. A few of the trials currently underway in San Francisco today are the POINT, SHINE, and ESETT trials The San Francisco Principal Investigator is J. NETT initiatives explore the narrow window of opportunity existing in the treatment of neurologic damage from pathologies including stroke, traumatic brain injury, seizures, and meningitis. The goal of the NETT program and SF-NETT is to create and maintain a clinical research infrastructure to perform streamlined Phase III clinical trials of new treatments for neurological emergencies including status epilepticus, traumatic brain and spinal cord injury, and stroke. SFGH has been awarded a National Institutes of Health (NIH) Neurological Emergencies Treatment Trials (NETT) network grant for its attempts to improve the immediate care and research of neuro emergencies with treatments delivered within minutes rather than hours after the onset of the issue. Mary’s) as well as Highland Hospital in Oakland. Spoke hospitals include all San Francisco ambulance destination hospitals (UCSF Medical Center, CPMC, Davies, Kaiser SF, St. Claude Hemphill and his colleagues at San Francisco General Hospital and UCSF are one of 17 academic centers selected as a “hub” for the NETT. Each hub acts as a local coordinating center for other participating hospitals, known as “spokes.” The hub of SF-NETT is in the Brain and Spinal Injury Center (BASIC) at San Francisco General Hospital. The researchers at BASIC have conducted numerous other smaller scale studies with the aim of improving the care and outcome of patients with traumatic brain injury, spinal cord injury and other neurosurgical disease processes.ĭr.
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